Explore by Lab Marker
White Blood Cell
White Blood Cell count is a measure of the total number of white blood cells in the blood. High or low levels can indicate infection, inflammation, or other health problems.
iollo markers that associate with White Blood Cell
Alanine
Alanine is an amino acid that can be metabolized to glucose and used as an energy source by white blood cells during immune activation and proliferation. Elevated alanine levels may reflect increased white blood cell activity.References
References
Jiong Yu, Qiaoling Pan, Jinfeng Yang, Chengxing Zhu, Linfeng Jin, Guangshu Hao, Xiaowei Shi, Hongcui Cao. Correlations of Complete Blood Count with Alanine and Aspartate Transaminase in Chinese Subjects and Prediction Based on Back-Propagation Artificial Neural Network (BP-ANN). NCBI (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487372/Unknown. Effect of a sustained-release formulation of β-alanine on blood cell count and biochemical parameters in young adults: A randomized, double-blind, placebo-controlled trial. Frontiers in Nutrition (2023). https://www.frontiersin.org/articles/10.3389/fnut.2023.1213105/fullUnknown. T Cell Activation Depends on Extracellular Alanine. ScienceDirect (2019). https://www.sciencedirect.com/science/article/pii/S2211124719310745Unknown. A Study of Korean Adults. J-Stage (2015). https://www.jstage.jst.go.jp/article/endocrj/55/6/55_K08E-077/_articleUnknown. Comparison of alanine aminotransferase, white blood cell count, and uric acid with metabolic syndrome in Korean adults. PubMed (2008). https://pubmed.ncbi.nlm.nih.gov/18753705/
Glutamine
Glutamine is a key fuel source for rapidly dividing cells like white blood cells. It supports white blood cell function, growth and proliferation. Low glutamine levels can impair immune cell responses.References
References
Brandon J. Desch, et al.. Dosing and Efficacy of Glutamine Supplementation in Human… Clinical Nutrition (2022). https://www.sciencedirect.com/science/article/pii/S0022316622096973M. Curi, et al.. Glutamine: Metabolism and Immune Function, Supplementation … - NCBI. Nutrients (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/M. Curi, et al.. Glutamine Metabolism and Its Role in Immunity, a Comprehensive Review. Nutrients (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070879/J. M. Mora, et al.. Why Is L-Glutamine Metabolism Important to Cells of the Immune … Clinical Nutrition (2022). https://www.sciencedirect.com/science/article/pii/S0022316622145943
Lactic acid
During inflammation and sepsis, increased white blood cell glycolysis leads to increased lactic acid production. Lactic acid levels can be elevated due to increased white blood cell activity and proliferation.References
References
Liu Y, Zheng J, Zhang D, Jing L. Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis. Journal of Clinical Laboratory Analysis (2019). https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.22942Funk DJ, Zhao Y, Gong M, et al.. Understanding critically ill sepsis patients with normal serum lactate: A retrospective analysis of three international datasets. Scientific Reports (2021). https://www.nature.com/articles/s41598-021-99581-6Farkas J. The complete blood count to diagnose septic shock - Farkas. Journal of Thoracic Disease (2021). https://jtd.amegroups.com/article/view/34598/htmlKim JH, Kim SY, Lee J, et al.. Evaluation of lactate, white blood cell count, neutrophil count, and C-reactive protein in the diagnosis of sepsis. American Journal of Emergency Medicine (2017). https://www.sciencedirect.com/science/article/abs/pii/S0009912017302205Zhang H, Liu Y, Zhang Q, et al.. Lactate and Immunosuppression in Sepsis. PMC - NCBI (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757670/