White Blood Cell count is a measure of the total number of white blood cells in the blood. High or low levels can indicate infection, inflammation, or other health problems.
Alanine is an amino acid that can be metabolized to glucose and used as an energy source by white blood cells during immune activation and proliferation. Elevated alanine levels may reflect increased white blood cell activity.
Jiong Yu, Qiaoling Pan, Jinfeng Yang, Chengxing Zhu, Linfeng Jin, Guangshu Hao, Xiaowei Shi, Hongcui Cao. Correlations of Complete Blood Count with Alanine and Aspartate Transaminase in Chinese Subjects and Prediction Based on Back-Propagation Artificial Neural Network (BP-ANN). NCBI (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487372/
Unknown. Effect of a sustained-release formulation of β-alanine on blood cell count and biochemical parameters in young adults: A randomized, double-blind, placebo-controlled trial. Frontiers in Nutrition (2023). https://www.frontiersin.org/articles/10.3389/fnut.2023.1213105/full
Unknown. Comparison of alanine aminotransferase, white blood cell count, and uric acid with metabolic syndrome in Korean adults. PubMed (2008). https://pubmed.ncbi.nlm.nih.gov/18753705/
Glutamine is a key fuel source for rapidly dividing cells like white blood cells. It supports white blood cell function, growth and proliferation. Low glutamine levels can impair immune cell responses.
During inflammation and sepsis, increased white blood cell glycolysis leads to increased lactic acid production. Lactic acid levels can be elevated due to increased white blood cell activity and proliferation.
Liu Y, Zheng J, Zhang D, Jing L. Neutrophil‐lymphocyte ratio and plasma lactate predict 28‐day mortality in patients with sepsis. Journal of Clinical Laboratory Analysis (2019). https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.22942
Funk DJ, Zhao Y, Gong M, et al.. Understanding critically ill sepsis patients with normal serum lactate: A retrospective analysis of three international datasets. Scientific Reports (2021). https://www.nature.com/articles/s41598-021-99581-6
