Homocysteine is an amino acid that can build up in the blood if there are deficiencies in certain B vitamins (B6, B12, or folate). High levels of homocysteine are associated with an increased risk of heart disease and stroke.

iollo markers that associate with Homocysteine


Betaine is used to re-methylate homocysteine back to methionine. Low betaine can contribute to elevated homocysteine levels.


Choline is oxidized to betaine, which is used to re-methylate homocysteine to methionine. Choline deficiency can lead to high homocysteine.


Homocysteine can be converted to cysteine via the transsulfuration pathway. Changes in cysteine levels often parallel changes in homocysteine.


Glycine is formed from serine and is interconverted with dimethylglycine. Glycine levels are linked to homocysteine metabolism.


Methionine is directly converted to homocysteine via several enzymatic steps. Elevated homocysteine is a marker of impaired methionine metabolism.


Serine condenses with homocysteine to form cystathionine in the transsulfuration pathway. Changes in serine can impact homocysteine levels.