Mean Cell Volume (MCV) is a measure of the average size of red blood cells. Abnormal MCV may indicate certain types of anemia or other blood disorders.

iollo markers that associate with Mean Cell Volume (MCV)


Glycine is involved in heme biosynthesis, which is critical for hemoglobin production in red blood cells. Alterations in glycine levels may impact the size and hemoglobin content of red blood cells, reflected in the MCV.


Serine, like glycine, is involved in the heme biosynthesis pathway. Changes in serine availability could affect heme production and consequently impact red blood cell size and MCV.

Succinic acid

Succinic acid is an intermediate in the citric acid cycle, which generates energy for red blood cell production. Abnormalities in succinic acid levels may impair red blood cell maturation and alter MCV.