Mean Cell Volume (MCV) is a measure of the average size of red blood cells. Abnormal MCV may indicate certain types of anemia or other blood disorders.
Glycine is involved in heme biosynthesis, which is critical for hemoglobin production in red blood cells. Alterations in glycine levels may impact the size and hemoglobin content of red blood cells, reflected in the MCV.
References
A. L. Hall, A. J. Friel, J. L. Friel, M. F. Daly, J. J. Strain, E. M. McSorley. Bioavailability of iron glycine as a fortificant in infant foods. American Journal of Clinical Nutrition (2023). https://www.sciencedirect.com/science/article/pii/S000291652318261X/pdf?md5=721d2bfcbcf8be5a6f64afefc754d6db&pid=1-s2.0-S000291652318261X-main.pdf/url
A. L. Hall, A. J. Friel, J. L. Friel, M. F. Daly, J. J. Strain, E. M. McSorley. Zoo Biology. Wiley Online Library (2024). https://onlinelibrary.wiley.com/doi/10.1002/zoo.21803/url
Serine, like glycine, is involved in the heme biosynthesis pathway. Changes in serine availability could affect heme production and consequently impact red blood cell size and MCV.
References
M.W.J., A.M.P., S.C., C.C.. Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in a Gambian population. Scientific Reports (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044158/
Various authors. ASPA 24th Congress Book of Abstract. Not provided (2021). https://iris.unipa.it/retrieve/e3ad8927-1709-da0e-e053-3705fe0a2b96/ASPA%2024th%20Congress%20Book%20of%20Abstract.pdf
A.M.A., S.A.A., A.A.A., M.A.A., N.A.A., A.A.A.. Association of mast-cell-related conditions with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorder (hEDS/HSD). Molecular Genetics & Genomic Medicine (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022617/
Not provided. Not provided. Not provided (2024). https://www.researchgate.net/publication/374233262_Proc-DSP-VI-2023-Bahawalpur
Succinic acid is an intermediate in the citric acid cycle, which generates energy for red blood cell production. Abnormalities in succinic acid levels may impair red blood cell maturation and alter MCV.
References
A. A. Adeyemi, O. O. Adebayo, A. O. Afolabi, et al.. Adenylosuccinic Acid Is a Non-Toxic Small Molecule In Vitro and In Vivo. Toxicology in Vitro (2023). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609790/
Y. H. Zhang, X. D. Zhang, Y. F. Liu, et al.. A comparative study with iron protein succinylate and ferrous succinate. Biological Trace Element Research (2023). https://www.sciencedirect.com/science/article/pii/S0753332223017894