Gamma glutamyl transpeptidase (GGT)

Gamma glutamyl transpeptidase is an enzyme that is primarily found in the liver and is a marker of liver function. Elevated levels may indicate liver damage or disease, especially alcohol-related liver disease.

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iollo markers that associate with Gamma glutamyl transpeptidase (GGT)

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Alanine

Alanine is an amino acid that can feed into the glutamic acid pool. Elevated alanine and GGT may reflect increased amino acid catabolism and liver dysfunction.

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Aspartic Acid

Aspartic acid is a precursor for glutamine and glutamic acid synthesis. Increased demand for these amino acids for glutathione production may lower aspartic acid when GGT is high.

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Cysteine

Cysteine is a rate-limiting precursor for glutathione synthesis. GGT-mediated glutathione breakdown increases the demand for cysteine to replenish glutathione levels. Cysteine depletion can increase GGT.

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Cystine

Cystine is the disulfide form of cysteine and influences glutathione status. Increased glutathione demand and breakdown by GGT may shift the balance from cysteine to cystine.

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Glutamic Acid

Glutamic acid is a substrate of GGT. Elevated GGT levels can indicate increased glutamic acid catabolism and are a marker of liver disease, alcohol abuse, and oxidative stress.

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Glutamine

Glutamine is a precursor for glutathione synthesis. Increased demand for glutathione due to oxidative stress or detoxification can deplete glutamine and increase GGT levels as glutathione is broken down.

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Glycine

Glycine is involved in glutathione synthesis. Altered glycine levels along with high GGT may indicate disrupted glutathione metabolism and oxidative stress, common in liver disease.

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Lactic acid

Lactic acid buildup can occur during oxidative stress and hepatic dysfunction, conditions that also increase GGT levels. Lactic acid may be a marker of the underlying oxidative or hepatic pathology.

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Taurine

Taurine has antioxidant and hepatoprotective effects. Depletion of taurine may occur in conditions that increase oxidative stress and GGT levels, such as liver disease and alcoholism.