Gamma glutamyl transpeptidase (GGT)
Gamma glutamyl transpeptidase is an enzyme that is primarily found in the liver and is a marker of liver function. Elevated levels may indicate liver damage or disease, especially alcohol-related liver disease.
iollo markers that associate with Gamma glutamyl transpeptidase (GGT)
Alanine
Alanine is an amino acid that can feed into the glutamic acid pool. Elevated alanine and GGT may reflect increased amino acid catabolism and liver dysfunction.
Aspartic Acid
Aspartic acid is a precursor for glutamine and glutamic acid synthesis. Increased demand for these amino acids for glutathione production may lower aspartic acid when GGT is high.
Cysteine
Cysteine is a rate-limiting precursor for glutathione synthesis. GGT-mediated glutathione breakdown increases the demand for cysteine to replenish glutathione levels. Cysteine depletion can increase GGT.
Cystine
Cystine is the disulfide form of cysteine and influences glutathione status. Increased glutathione demand and breakdown by GGT may shift the balance from cysteine to cystine.
Glutamic Acid
Glutamic acid is a substrate of GGT. Elevated GGT levels can indicate increased glutamic acid catabolism and are a marker of liver disease, alcohol abuse, and oxidative stress.
Glutamine
Glutamine is a precursor for glutathione synthesis. Increased demand for glutathione due to oxidative stress or detoxification can deplete glutamine and increase GGT levels as glutathione is broken down.
Glycine
Glycine is involved in glutathione synthesis. Altered glycine levels along with high GGT may indicate disrupted glutathione metabolism and oxidative stress, common in liver disease.
Lactic acid
Lactic acid buildup can occur during oxidative stress and hepatic dysfunction, conditions that also increase GGT levels. Lactic acid may be a marker of the underlying oxidative or hepatic pathology.
Taurine
Taurine has antioxidant and hepatoprotective effects. Depletion of taurine may occur in conditions that increase oxidative stress and GGT levels, such as liver disease and alcoholism.