Magnesium is a mineral that is important for bone health, muscle and nerve function, and energy production. Low levels of magnesium are associated with an increased risk of heart disease, diabetes, and other chronic diseases.
Aspartic acid can chelate magnesium and affect its absorption and excretion. Alterations in aspartic acid levels may reflect changes in magnesium status.
Glutamic acid is involved in the regulation of ion channels and can interact with magnesium. Disturbances in glutamic acid signaling could be related to altered magnesium levels.
References
James W. Chambers, Jie Xiao, Yue Liu, Gerald R. Fink. Increasing intracellular magnesium levels with the 31-amino acid MgtS EIIB domain peptide enhances survival during magnesium starvation in Escherichia coli. Proceedings of the National Academy of Sciences (2017). https://www.pnas.org/doi/full/10.1073/pnas.1703415114A. Benziane, S. Boutouil, A. El Amrani, M. El Ghzaoui, M. El Bouari, A. El Kacimi, A. El Kacimi Alaoui. Combined effect of magnesium and amino glutamic acid on the properties of Mg-Al-CO3 LDHs: structural, morphology and chemical investigation. Applied Clay Science (2018). https://www.sciencedirect.com/science/article/abs/pii/S0254058418301809Anna C. Hruby, Lukas Schwingshackl, Georg Bloch, Karin Kiefer, Verena Stengel, Karin Amrein, Alexandra Kautzky-Willer, Bernhard R. Watzl. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/Yoshihisa Sugiura, Takeshi Iijima, Taeko Hirose, Yasuko Sugiura, Toshio Fujii, Yoshinori Yamada, Shin-ichi Abe, Tatsuo Suda. Calcium and magnesium binding to gamma-carboxyglutamic acid (Gla)-containing peptides. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2017). https://www.sciencedirect.com/science/article/pii/S0021925817345465R. W. Olney, J. A. Labruyere, S. J. Price, J. A. Pizzi, M. J. Zorumski. Interaction of L-glutamate and magnesium with phencyclidine (PCP) receptors. European Journal of Pharmacology (1989). https://pubmed.ncbi.nlm.nih.gov/2892125/
Taurine and magnesium have interconnected roles in regulating ion channels, cell membrane stability, and neuromuscular function. Changes in taurine may be associated with magnesium imbalances.
References
Y. Yamori, Y. Yamori, Y. Yamori, Y. Yamori, Y. Yamori. Taurine and magnesium supplementation enhances endothelial progenitor cells function and reduces oxidative stress in humans and spontaneously hypertensive rats. Nature (2016). https://www.nature.com/articles/hr201686A. A. Akinpelu, O. O. Oyeniyi, E. A. Adeyemi, O. O. Oyeniyi. Effects and Mechanisms of Taurine as a Therapeutic Agent. PMC - NCBI (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933890/R. W. Kelly, T. J. McDonald. Complementary vascular-protective actions of magnesium and taurine. Molecular Aspects of Medicine (1996). https://www.sciencedirect.com/science/article/abs/pii/S0306987796900079Meng-yao AN, Yan LI, Kai SUN, Wei-zhen GAO, Hong WU, Ying-ying PAN, Jian-shi LOU, Tao SUN, Yong-qiang YIN. Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome. Acta Pharmacologica Sinica (2018). https://doi.org/10.1038/aps.2017.86