Apolipoprotein A1 is a protein found in HDL cholesterol and is used to estimate the total number of HDL particles in the blood. Low levels of Apolipoprotein A1 are associated with an increased risk of heart disease.

iollo markers that associate with Apolipoprotein A1

Arachidonic acid

Arachidonic acid can be incorporated into phospholipids in HDL particles. Its levels may influence HDL inflammatory properties and apoA1 function.

Lysophosphatidylcholine a C18:1

Unsaturated lysophosphatidylcholine species like LPC a C18:1 are generated during HDL remodeling and affect apoA1 conformation on HDL particles.

Lysophosphatidylcholine a C18:2

Lysophosphatidylcholine is generated from phosphatidylcholine in HDL by enzymes like LCAT, affecting HDL maturation and apoA1 levels. LPC a C18:2 is a common species.

Phosphatidylcholine aa C34:3

Phosphatidylcholine composition in HDL influences particle size, cholesterol efflux capacity and other functions related to apoA1.

Phosphatidylcholine aa C36:4

The fatty acid composition of phosphatidylcholines in HDL, including species like PC aa C36:4, affects HDL’s ability to accept cholesterol via apoA1.

Phosphatidylcholine aa C36:5

Phosphatidylcholine is a key component of HDL particles, of which apolipoprotein A1 is the main structural protein. Changes in phosphatidylcholine composition can affect HDL function and apoA1 levels.

Phosphatidylcholine aa C36:6

Highly unsaturated phosphatidylcholine species like PC aa C36:6 are enriched in HDL and influence HDL’s atheroprotective properties, which are mediated by apoA1.

Phosphatidylcholine aa C38:5

PC aa C38:5 is an unsaturated phospholipid that may be enriched in HDL, with effects on HDL function and apoA1 interactions.