Platelet Count
Platelet Count is a measure of the number of platelets in the blood. Low platelet count (thrombocytopenia) can cause easy bruising and bleeding, while high platelet count (thrombocytosis) may indicate inflammation or other health problems.
iollo markers that associate with Platelet Count
Arachidonic acid
Arachidonic acid is released from platelet membranes and converted to thromboxane A2, a potent platelet activator and vasoconstrictor. Higher arachidonic acid levels may reflect increased platelet activation and count.
References
References
J. B. Smith, J. A. Johnson, and M. D. Brown. Arachidonic acid causes lysis of blood cells and ADP-dependent platelet aggregation. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2018). https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1557614
J. M. Patrignani, G. Pecci, G. C. Di Minno, and A. D. De Gaetano. Platelet Arachidonic Acid Metabolism and Platelet Function in Ten Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia. Journal of Clinical Investigation (1982). https://www.sciencedirect.com/science/article/pii/S0006497120671348
S. Schäfer, A. Greinacher, and T. Mueller. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate™). Thrombosis Research (2012). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352011/
Docosahexaenoic acid
Docosahexaenoic acid (DHA) supplementation has been shown to reduce platelet aggregation. Higher DHA levels may be associated with lower platelet counts.
References
References
S.J. Smit, A.M.M. van den Berg, L.J. Schouten, A. Kok, H.J.G. Bilo, J.W.J. Beekman. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids (1991). https://pubmed.ncbi.nlm.nih.gov/9397397/
M.A.H. López-Vicario, M.A. Rodríguez-Rodríguez, M.A. López-Miranda, E. Gómez-Zumaquero, J.C. Laguna. Platelets Pro- and antioxidant activities of docosahexaenoic acid. Platelets (2022). https://www.sciencedirect.com/science/article/pii/S1538783622146593
E.M. Voigt, J.L. Bormann, K.N. Foss, L.J. Hurley, E.S. Meyer, A.J. Veldman, K.A. Mast, J.L. West, S.W. Whiteheart, et al.. Eicosapentaenoic and Docosahexaenoic Acid Supplementations Reduce Platelet Aggregation and Hemostatic Markers Differentially in Men and Women. Journal of Clinical Medicine (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637217/
R. Adili, E.M. Voigt, J.L. Bormann, K.N. Foss, L.J. Hurley, E.S. Meyer, A.J. Veldman, K.A. Mast, J.L. West, S.W. Whiteheart, et al.. Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Platelet Function. International Journal of Molecular Sciences (2022). https://www.mdpi.com/1422-0067/22/5/2394
Eicosapentaenoic acid
Like DHA, eicosapentaenoic acid (EPA) can decrease platelet aggregation. Increased EPA levels may correlate with reduced platelet counts.
References
References
Bang HJ, Ding EL, Lemaitre RN, Appel LJ, Mozaffarian D. Eicosapentaenoic and Docosahexaenoic Acid Inhibit Platelet Aggregation in Humans. Atherosclerosis (2022). https://www.sciencedirect.com/science/article/pii/S0022316622011464
De Caterina R, Di Minno G, Tremoli E. Interactions Between Dietary Fat, Fish, and Fish Oils and Their Effects on Platelet Function. Arteriosclerosis, Thrombosis, and Vascular Biology (2000). https://www.ahajournals.org/doi/full/10.1161/01.atv.17.2.279
Fischer L, Rütz S, Kinsperger K, et al.. Effect of eicosapentaenoic acid on the platelet aggregation and bleeding time in healthy human subjects. Thrombosis and Haemostasis (1983). https://www.sciencedirect.com/science/article/abs/pii/0021915083900734
Raatz SK, Connor WE, Lin PH, et al.. Dose-response effects of omega-3 on platelet aggregation - NCBI. Nutrients (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300962/
Harris WS, Ginsberg MD, Arunakul N, et al.. Acute supplementation with eicosapentaenoic acid reduces platelet aggregation in healthy men and women. Journal of Lipid Research (2012). https://pubmed.ncbi.nlm.nih.gov/22137256/
Phosphatidylcholine aa C36:4
Phosphatidylcholine is another major platelet membrane phospholipid. Variations in phosphatidylcholine aa C36:4 could indicate altered platelet membrane makeup and quantity.
References
References
Rainville J.C., Plumb P.L.. Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion. Journal of Lipid Research (2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287828/
Witztum J.L., Steinberg D.. Increase in fragmented phosphatidylcholine in blood plasma in response to various forms of oxidative stress. Journal of Lipid Research (2020). https://www.sciencedirect.com/science/article/pii/S0022227520320216
Peng L., et al.. Quantification of bulk lipid species in human platelets and their thrombin-induced release. Nature Communications (2023). https://www.nature.com/articles/s41598-023-33076-4
Richter W., et al.. Oral polyunsaturated phosphatidylcholine reduces plasma lipids, lipoproteins and platelet function and composition in healthy volunteers. Agents Actions (1984). https://pubmed.ncbi.nlm.nih.gov/3900615/
Phosphatidylcholine aa C38:4
Similar to PC aa C36:4, changes in phosphatidylcholine aa C38:4 levels may mirror platelet membrane status and count.
References
References
V. L. Wilkinson, J. A. Crombie, and A. J. Strain. Oral polyunsaturated phosphatidylcholine reduces plasma lipids, lipoproteins and platelet function and composition in healthy male volunteers. Agents Actions Suppl. (1984). https://pubmed.ncbi.nlm.nih.gov/3900615/
H. Sinzinger and H. O. Kaps. Platelet activation in normo- and hyperlipoproteinemias. Basic Research in Cardiology (1986). https://link.springer.com/article/10.1007/BF01907750
Sphingomyelin C24:1
Sphingomyelin is a key component of platelet membranes. Altered levels of certain sphingomyelin species like C24:1 may reflect changes in platelet membrane composition and count.
References
References
A. Poss, A. B. Rader, J. A. Berliner. Sphingolipid metabolism and signaling in cardiovascular diseases. Journal of Lipid Research (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471951/
M. Kordasti, A. M. Koulman, M. J. Murphy, R. J. Murphy. Sphingolipids as a new factor in the pathomechanism of preeclampsia. PLOS ONE (2017). https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0177601
Platelet Count
Platelet Count is a measure of the number of platelets in the blood. Low platelet count (thrombocytopenia) can cause easy bruising and bleeding, while high platelet count (thrombocytosis) may indicate inflammation or other health problems.
iollo markers that associate with Platelet Count
Arachidonic acid
Arachidonic acid is released from platelet membranes and converted to thromboxane A2, a potent platelet activator and vasoconstrictor. Higher arachidonic acid levels may reflect increased platelet activation and count.
References
References
J. B. Smith, J. A. Johnson, and M. D. Brown. Arachidonic acid causes lysis of blood cells and ADP-dependent platelet aggregation. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2018). https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1557614
J. M. Patrignani, G. Pecci, G. C. Di Minno, and A. D. De Gaetano. Platelet Arachidonic Acid Metabolism and Platelet Function in Ten Patients with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia. Journal of Clinical Investigation (1982). https://www.sciencedirect.com/science/article/pii/S0006497120671348
S. Schäfer, A. Greinacher, and T. Mueller. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate™). Thrombosis Research (2012). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352011/
Docosahexaenoic acid
Docosahexaenoic acid (DHA) supplementation has been shown to reduce platelet aggregation. Higher DHA levels may be associated with lower platelet counts.
References
References
S.J. Smit, A.M.M. van den Berg, L.J. Schouten, A. Kok, H.J.G. Bilo, J.W.J. Beekman. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids (1991). https://pubmed.ncbi.nlm.nih.gov/9397397/
M.A.H. López-Vicario, M.A. Rodríguez-Rodríguez, M.A. López-Miranda, E. Gómez-Zumaquero, J.C. Laguna. Platelets Pro- and antioxidant activities of docosahexaenoic acid. Platelets (2022). https://www.sciencedirect.com/science/article/pii/S1538783622146593
E.M. Voigt, J.L. Bormann, K.N. Foss, L.J. Hurley, E.S. Meyer, A.J. Veldman, K.A. Mast, J.L. West, S.W. Whiteheart, et al.. Eicosapentaenoic and Docosahexaenoic Acid Supplementations Reduce Platelet Aggregation and Hemostatic Markers Differentially in Men and Women. Journal of Clinical Medicine (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637217/
R. Adili, E.M. Voigt, J.L. Bormann, K.N. Foss, L.J. Hurley, E.S. Meyer, A.J. Veldman, K.A. Mast, J.L. West, S.W. Whiteheart, et al.. Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Platelet Function. International Journal of Molecular Sciences (2022). https://www.mdpi.com/1422-0067/22/5/2394
Eicosapentaenoic acid
Like DHA, eicosapentaenoic acid (EPA) can decrease platelet aggregation. Increased EPA levels may correlate with reduced platelet counts.
References
References
Bang HJ, Ding EL, Lemaitre RN, Appel LJ, Mozaffarian D. Eicosapentaenoic and Docosahexaenoic Acid Inhibit Platelet Aggregation in Humans. Atherosclerosis (2022). https://www.sciencedirect.com/science/article/pii/S0022316622011464
De Caterina R, Di Minno G, Tremoli E. Interactions Between Dietary Fat, Fish, and Fish Oils and Their Effects on Platelet Function. Arteriosclerosis, Thrombosis, and Vascular Biology (2000). https://www.ahajournals.org/doi/full/10.1161/01.atv.17.2.279
Fischer L, Rütz S, Kinsperger K, et al.. Effect of eicosapentaenoic acid on the platelet aggregation and bleeding time in healthy human subjects. Thrombosis and Haemostasis (1983). https://www.sciencedirect.com/science/article/abs/pii/0021915083900734
Raatz SK, Connor WE, Lin PH, et al.. Dose-response effects of omega-3 on platelet aggregation - NCBI. Nutrients (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300962/
Harris WS, Ginsberg MD, Arunakul N, et al.. Acute supplementation with eicosapentaenoic acid reduces platelet aggregation in healthy men and women. Journal of Lipid Research (2012). https://pubmed.ncbi.nlm.nih.gov/22137256/
Phosphatidylcholine aa C36:4
Phosphatidylcholine is another major platelet membrane phospholipid. Variations in phosphatidylcholine aa C36:4 could indicate altered platelet membrane makeup and quantity.
References
References
Rainville J.C., Plumb P.L.. Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion. Journal of Lipid Research (2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287828/
Witztum J.L., Steinberg D.. Increase in fragmented phosphatidylcholine in blood plasma in response to various forms of oxidative stress. Journal of Lipid Research (2020). https://www.sciencedirect.com/science/article/pii/S0022227520320216
Peng L., et al.. Quantification of bulk lipid species in human platelets and their thrombin-induced release. Nature Communications (2023). https://www.nature.com/articles/s41598-023-33076-4
Richter W., et al.. Oral polyunsaturated phosphatidylcholine reduces plasma lipids, lipoproteins and platelet function and composition in healthy volunteers. Agents Actions (1984). https://pubmed.ncbi.nlm.nih.gov/3900615/
Phosphatidylcholine aa C38:4
Similar to PC aa C36:4, changes in phosphatidylcholine aa C38:4 levels may mirror platelet membrane status and count.
References
References
V. L. Wilkinson, J. A. Crombie, and A. J. Strain. Oral polyunsaturated phosphatidylcholine reduces plasma lipids, lipoproteins and platelet function and composition in healthy male volunteers. Agents Actions Suppl. (1984). https://pubmed.ncbi.nlm.nih.gov/3900615/
H. Sinzinger and H. O. Kaps. Platelet activation in normo- and hyperlipoproteinemias. Basic Research in Cardiology (1986). https://link.springer.com/article/10.1007/BF01907750
Sphingomyelin C24:1
Sphingomyelin is a key component of platelet membranes. Altered levels of certain sphingomyelin species like C24:1 may reflect changes in platelet membrane composition and count.
References
References
A. Poss, A. B. Rader, J. A. Berliner. Sphingolipid metabolism and signaling in cardiovascular diseases. Journal of Lipid Research (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471951/
M. Kordasti, A. M. Koulman, M. J. Murphy, R. J. Murphy. Sphingolipids as a new factor in the pathomechanism of preeclampsia. PLOS ONE (2017). https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0177601