Mean Platelet Volume (MPV) is a measure of the average size of platelets in the blood. Abnormal MPV may indicate certain types of blood disorders or other health problems.
Arachidonic acid is released from platelet membranes upon activation and contributes to platelet aggregation. Higher arachidonic acid levels may increase mean platelet volume.
Docosahexaenoic acid (DHA) supplementation has been shown to decrease mean platelet volume, likely by altering platelet membrane composition and reducing platelet reactivity.
Like DHA, eicosapentaenoic acid (EPA) may decrease mean platelet volume by being incorporated into platelet membranes and reducing platelet activation.
Phosphatidylcholines are major structural lipids in platelet membranes. Changes in phosphatidylcholine composition may impact platelet size and mean volume.
Sphingomyelins are important components of platelet membranes. Alterations in sphingomyelin composition, such as increased C24:1, could affect mean platelet volume.
References
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