Mean Platelet Volume (MPV) is a measure of the average size of platelets in the blood. Abnormal MPV may indicate certain types of blood disorders or other health problems.
Arachidonic acid is released from platelet membranes upon activation and contributes to platelet aggregation. Higher arachidonic acid levels may increase mean platelet volume.
Smith, J.B., Rittenhouse-Simmons, S., and Silver, M.J.. Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2-dependent pathway. Biochemical and Biophysical Research Communications (1984). https://pubmed.ncbi.nlm.nih.gov/6319669/
Dechatelet, L.R., and Born, G.V.R.. Role of arachidonic acid metabolism in human platelet activation and aggregation. Thrombosis and Haemostasis (1982). https://pubmed.ncbi.nlm.nih.gov/3161324/
Gurbel, P.A., and Tantry, U.S.. Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Purinergic Receptor–Dependent Pathway in Patients with Coronary Artery Disease. Circulation (2006). https://www.ahajournals.org/doi/10.1161/circulationaha.105.596627
Docosahexaenoic acid (DHA) supplementation has been shown to decrease mean platelet volume, likely by altering platelet membrane composition and reducing platelet reactivity.
Harris WS, et al.. Eicosapentaenoic acid and docosahexaenoic acid from fish oils: effects on platelet function and platelet fatty acid composition. Journal of Clinical Investigation (2003). https://pubmed.ncbi.nlm.nih.gov/12530552/
Like DHA, eicosapentaenoic acid (EPA) may decrease mean platelet volume by being incorporated into platelet membranes and reducing platelet activation.
Phosphatidylcholines are major structural lipids in platelet membranes. Changes in phosphatidylcholine composition may impact platelet size and mean volume.
Similar to C36:4, variations in phosphatidylcholine C38:4 in platelet membranes could influence mean platelet volume.
[Last Name 1], [Last Name 2], …, [Last Name N]. Efficient megakaryopoiesis and platelet production require significant phospholipid remodeling. [Journal Name] (2023). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934665/
Sphingomyelins are important components of platelet membranes. Alterations in sphingomyelin composition, such as increased C24:1, could affect mean platelet volume.
Di Pietro, P.; Izzo, C.; Abate, A.C.; Iesu, P.; Rusciano, M.R.; Venturini, E.; Visco, V.; Sommella, E.; Ciccarelli, M.; Carrizzo, A.; et al.. The Dark Side of Sphingolipids: Searching for Potential Cardiovascular Biomarkers. Biomolecules (2023). https://doi.org/10.3390/biom13010168
Amano, S.; Koyama, H.; Kuwano, K.; Kondo, K.; Kobayashi, K.; Kusunoki, S.; Kubota, K.; Kusakabe, T.; Kakihana, M.; Koyama, T.; et al.. Acid sphingomyelinase mediates murine acute lung injury following intratracheal lipopolysaccharide challenge. American Journal of Physiology-Lung Cellular and Molecular Physiology (2017). https://doi.org/10.1152/ajplung.00317.2016
Kim, H.J.; Park, J.H.; Kim, D.H.; Kim, Y.S.; Kim, J.H.; Kim, S.H.; Kim, B.J.; Kim, K.S.; Kim, S.G.; Kim, Y.K.; et al.. Sphingolipid Profiling: A Promising Tool for Stratifying the Metabolic Syndrome. Metabolites (2022). https://doi.org/10.3390/metabo12020157
