Bicarbonate is an electrolyte that helps regulate blood pH. Low levels of bicarbonate (metabolic acidosis) may indicate kidney disease, lung disease, or other health problems.

iollo markers that associate with Bicarbonate


Alanine is a gluconeogenic amino acid that can be converted to pyruvate and enter the citric acid cycle, potentially increasing bicarbonate generation. Alanine levels tend to increase in metabolic acidosis as the body tries to raise bicarbonate.

Glutamic Acid

Glutamic acid is an acidic amino acid that can be deaminated to alpha-ketoglutarate, an intermediate in the citric acid cycle. This process generates bicarbonate to balance the acid load of glutamic acid.


Glutamine is metabolized to glutamate and then alpha-ketoglutarate, which can enter the citric acid cycle and increase bicarbonate production. Glutamine supplementation has been shown to increase bicarbonate levels in some studies.

Lactic acid

Lactic acid production consumes bicarbonate to maintain acid-base balance. Excess lactic acid production, as occurs in lactic acidosis, can deplete bicarbonate levels leading to metabolic acidosis.