Hypoxanthine is a purine derivative that is oxidized by xanthine oxidase to form xanthine and subsequently uric acid. Elevated hypoxanthine contributes to higher uric acid levels.
References
Zhao, X., Zhang, L., Zhang, J., Zhang, W., Zhang, Y., & Zhang, Q.. Study on the diagnosis of gout with xanthine and hypoxanthine. Journal of Zhejiang University Science B (2005). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595306/
Xanthine is a purine base that is oxidized by xanthine oxidase to form uric acid. Increased xanthine levels directly lead to increased uric acid production.
References
Yoshifumi Ishibashi, Yusuke Nakamura, Hiroshi Saito, Hiroshi Kawashiri, Yukio Ozaki, Shigetaka Noma, Masahiro Kawakami. Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease. Hypertension Research (2023). https://doi.org/10.1038/s41440-022-00891-7Masaharu Nagao, Hiroshi Kawabata, Katsuhiko Kawano, Hirotaka Watanabe, Tetsuo Noda, Hiroshi Koyama. Quantification of uric acid, xanthine and hypoxanthine in human serum. Journal of Chromatography B (2006). https://www.sciencedirect.com/science/article/pii/S157002320600225XHiroshi Sekizuka. Uric acid, xanthine oxidase, and vascular damage. Hypertension Research (2022). https://doi.org/10.1038/s41440-022-00891-7