Explore by Lab Marker
Mean Corpuscular Hemoglobin (MCH)
Mean Corpuscular Hemoglobin (MCH) is a measure of the average amount of hemoglobin in each red blood cell. Abnormal MCH may indicate certain types of anemia or other blood disorders.
iollo markers that associate with Mean Corpuscular Hemoglobin (MCH)
Alanine
Alanine is involved in the heme biosynthesis pathway by providing a carbon skeleton. Reduced alanine availability could limit heme and hemoglobin synthesis, decreasing MCH.References
References
N. P. Kamat, M. A. Kamat. Biochemistry, Heme Synthesis - StatPearls - NCBI Bookshelf. StatPearls Publishing (2021). https://www.ncbi.nlm.nih.gov/books/NBK537329/A. Ganz. Iron and hepcidin: a story of recycling and balance. Hematology (2013). https://ashpublications.org/hematology/article/2013/1/1/20722/Iron-and-hepcidin-a-story-of-recycling-and-balance/urlMoro T, Holasek S, Baranyi A, et al.. Branched-chain amino acids are linked with iron metabolism. Annals of Translational Medicine (2020). https://atm.amegroups.org/article/view/57506/html/urlG. Lambert, D. Jaffe, D. H. Wolf. Structure and function of enzymes in heme biosynthesis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2011). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895239/
Glutamic Acid
Glutamic acid is a precursor for the heme biosynthesis pathway. Low glutamic acid levels may impair heme production, resulting in decreased hemoglobin content and MCH in red cells.References
References
M. Fernández-Fuertes, M. D. MacLeod, J. A. Woolliams, P. M. van der Aa, J. J. Windig, M. F. Rothschild, A. C. F. M. Beerda, J. F. M. Spoolder. Genome-wide association studies for 30 haematological and blood biochemistry traits in a heavy pig population. Scientific Reports (2019). https://www.nature.com/articles/s41598-019-43297-1
Succinic acid
Succinic acid is an intermediate in the heme biosynthesis pathway. Elevated levels may indicate a block in heme synthesis, potentially leading to reduced hemoglobin production and lower MCH.References
References
Detraux D, Caruso M. A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions. NCBI Gene Expression Omnibus (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425175/Detraux D, Caruso M, LF, MF, SM, JM, TA, PR. A critical role for heme synthesis and succinate in the regulation of pluripotent states. eLife (2023). https://elifesciences.org/articles/78546