Lipase is an enzyme produced by the pancreas that helps digest fats. High levels of lipase in the blood may indicate pancreatitis or other pancreatic disorders.
Arachidonic acid is released from cell membranes by phospholipase A2 enzymes, which are activated by lipase. Elevated lipase may indicate increased arachidonic acid release.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that can be released from cell membranes by lipase activity. High lipase levels may lead to increased DHA release.
Narendra Singh, Xin-Yun Lu, and Subba Rao Chaganti. Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as triacylglycerol, increases brain DHA content and improves brain function in adult mammals. Scientific Reports (2017). https://www.nature.com/articles/s41598-017-11766-0
Subba Rao Chaganti, Xin-Yun Lu, and Narendra Singh. Potential role of hepatic lipase in the accretion of docosahexaenoic acid in the brain. Nutrition Research (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325639/
Subba Rao Chaganti, Xin-Yun Lu, and Narendra Singh. Potential role of hepatic lipase in the accretion of docosahexaenoic acid in the brain. Nutrition Research (2021). https://pubmed.ncbi.nlm.nih.gov/34197964/
H. Zhang, S. Zhang, L. Zhang, et al.. Lysosomal acid lipase in lipid metabolism and beyond. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482091/
M. A. Nascimento, J. A. Oliveira, L. M. S. Pereira, et al.. Molecular and histological traits of reduced lysosomal acid lipase activity in mice. Lipids in Health and Disease (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602623/
A. Chojnacka, W. Gładkowski. Production of Structured Phosphatidylcholine with High Content of Myristic Acid by Lipase-Catalyzed Acidolysis and Interesterification. Catalysts (2018). https://www.mdpi.com/2073-4344/8/7/281
Stearic acid is a long-chain saturated fatty acid that can be liberated from lipids by lipase activity. High lipase may increase stearic acid levels.
Journal of Agricultural and Food Chemistry. Study of the Lipase-Catalyzed Esterification of … - ACS Publications. Journal of Agricultural and Food Chemistry (2009). https://pubs.acs.org/doi/abs/10.1021/ie900406x
Brejchova K, Radner FPW, Balas L, Paluchova V, Cajka T, Chodounska H, Kudova E, Schratter M, Schreiber R, Durand T, et al.. Distinct roles of adipose triglyceride lipase and hormone-sensitive … The Journal of Biological Chemistry (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812821/
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. Evidence for distinct metabolic utilization of stearic acid in … Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (1993). https://www.sciencedirect.com/science/article/pii/095528639390028U
