Total Protein is a measure of all the proteins in the blood, including albumin and globulins. Abnormal levels of total protein may indicate liver or kidney disease, or other health problems.
Alanine is an amino acid that is a component of many proteins in the body. Higher alanine levels may reflect increased protein turnover or breakdown, which could correlate with changes in total serum protein levels.
Glutamine is the most abundant free amino acid in the body and is used in the biosynthesis of proteins. Glutamine levels may relate to overall protein status as reflected by the total protein clinical lab marker.
Leucine is an essential amino acid that stimulates protein synthesis and inhibits protein breakdown in muscle. Leucine levels could potentially impact total body protein balance and the total protein lab measurement.
References
Adewale O. Ogunleye, Anastasios Phillippou, et al.. Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino acid supplementation on muscle mass and physical performance in elderly men and women. European Journal of Clinical Nutrition (2015). https://www.nature.com/articles/ejcn201591José A. Morales, et al.. Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis. Nutrients (2015). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446786/Robert R. Wolfe, et al.. Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Balance in Healthy Young Men. The Journal of Nutrition (2022). https://www.sciencedirect.com/science/article/pii/S0022316622071395Xin-Yu Zhang, et al.. Research progress in the role and mechanism of Leucine in regulating animal growth and development. Animal Nutrition (2023). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691278/Michael J. Rennie, et al.. Kinetic modeling of leucine-mediated signaling and protein metabolism in skeletal muscle. Cell Metabolism (2024). https://www.sciencedirect.com/science/article/pii/S2589004223027116