Skip to main content
Ferritin is a protein that stores iron in the body. Low levels of ferritin can indicate iron deficiency, while high levels may indicate iron overload or inflammation.

iollo markers that associate with Ferritin

Alanine

Alanine is a substrate for the synthesis of glucose, which requires iron-containing enzymes. Altered ferritin levels could affect glucose production from alanine and alanine levels.
A. López-García, M. A. Gómez-Ambrosi, F. Casanova, et al.. Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase in Nonalcoholic Fatty Liver Disease: A Prospective Study. Nutrients (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695258/X. Liu, Y. Li, J. Li, et al.. Serum iron and risk of nonalcoholic fatty liver disease and its histological severity: A prospective cohort study. Scientific Reports (2021). https://www.nature.com/articles/s41598-021-89991-xS. K. Al-Habdan, A. A. Al-Mazyad, A. A. Al-Johani, et al.. Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin in Thalassemia Major Patients. Cureus (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205361/

Carnitine

Carnitine is involved in fatty acid metabolism and energy production in mitochondria. Ferritin levels may impact carnitine utilization since iron is a cofactor for carnitine synthesis enzymes. Abnormal ferritin could thus alter carnitine levels.
B. R. Bieber, J. L. Lamar, and J. M. Saavedra. Inadequate iron availability as a possible cause of low serum carnitine. Journal of Inherited Metabolic Disease (1989). https://link.springer.com/article/10.1007/BF02093725S. S. Ahmed, S. A. Al-Dharrab, and A. Al-Megrin. Serum carnitine levels in children with iron-deficiency anemia. Nutrition (2006). https://pubmed.ncbi.nlm.nih.gov/16728358/

Glutamic Acid

Glutamic acid is involved in the citric acid cycle and amino acid metabolism. Iron-containing enzymes like aconitase are critical for the citric acid cycle. Ferritin levels may thus influence glutamic acid utilization.
Zhang, W., Nassiri, F., Mason, W., Aldape, K.D., Zadeh, G., & Chen, E.X.. “Glutamine reliance in cell metabolism”. Experimental & Molecular Medicine (2020). https://www.nature.com/articles/s12276-020-00504-8ScienceDirect Topics. “Krebs Cycle - an overview”. ScienceDirect (nan). https://www.sciencedirect.com/topics/earth-and-planetary-sciences/krebs-cycleStatPearls. “Biochemistry, Citric Acid Cycle”. NCBI Bookshelf (nan). https://www.ncbi.nlm.nih.gov/books/NBK541072/
I