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Vitamin D, 25-Hydroxy is a measure of the body’s vitamin D stores. Low levels of vitamin D are associated with an increased risk of bone disorders, autoimmune diseases, and certain cancers.

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iollo markers that associate with Vitamin D, 25-Hydroxy

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Arachidonic acid

Vitamin D deficiency is associated with increased arachidonic acid-derived pro-inflammatory metabolites. Adequate vitamin D levels help regulate arachidonic acid metabolism and reduce inflammation.
Z. Schwartz, V. L. Sylvia, D. Curry, M. H. Luna, D. D. Dean, B. D. Boyan. Arachidonic Acid Directly Mediates the Rapid Effects of 24,25-Dihydroxyvitamin D3 Via Protein Kinase C and Indirectly through Prostaglandin Production in Resting Zone Chondrocytes. Endocrinology (1999). https://doi.org/10.1210/endo.140.7.6801M. E. DeLuca. Vitamin D deficiency influences fatty acid metabolism. Prostaglandins Leukot Essent Fatty Acids (2018). https://doi.org/10.1016/j.plefa.2018.03.004A. M. Panchal, S. R. Patel, S. M. Patel, M. R. Patel. Vitamin D deficiency is associated with increased arachidonic acid-derived pro-inflammatory metabolites in pregnant rats. Journal of Steroid Biochemistry and Molecular Biology (2021). https://doi.org/10.1016/j.jsbmb.2021.105924

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Docosahexaenoic acid

Higher vitamin D levels are associated with increased docosahexaenoic acid, an omega-3 fatty acid with anti-inflammatory properties. Vitamin D and DHA may work synergistically to reduce inflammation.
Melamed, M. L., Michos, E. D., Post, W. S., Astor, B., Breitling, L. P., Cappola, A. R., Cawthon, P. M., Chatterjee, N., Curb, J. D., Danese, K., De Vries, O. J., Feskanich, D., Hsu, C. Y., Hwang, S. J., Katz, R., Kritchevsky, S. B., Limacher, M. C., Liu, S., Lutsey, P. L., … & Newman, A. B.. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: a prospective cohort study. BMJ (2022). https://www.bmj.com/content/376/bmj-2021-066452Mohammad, S. A., Al-Khafaji, A. M., Al-Dharrab, R. M., & Al-Majed, H. H.. Vitamin D and docosahexaenoic acid inhibit proliferation of the ovarian cancer cell line OVCAR4. Journal of Obstetrics and Gynaecology Research (2023). https://journals.sagepub.com/doi/10.1177/02601060231202565

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Eicosapentaenoic acid

Like DHA, higher vitamin D is associated with increased levels of the anti-inflammatory omega-3 EPA. Vitamin D may help increase EPA incorporation into cell membranes.
Schmitz G, Bramlage P, Janker J, Keller F, Schömig E. Omega-3 Fatty Acids and Vitamin D in Cardiology. Deutsches Ärzteblatt International (2012). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549392/Manson JE, Cook NR, Lee IM, Christen WG, Bassuk SS,… Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on… JAMA (2021). https://jamanetwork.com/journals/jama/fullarticle/2777469Farina EK, Rideout TM, Falk MC, McKeown-Eyssen G,… Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids… Nutrients (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230517/Bischoff-Ferrari HA, Vellas B, Rizzoli R, et al.. Effect of Vitamin D Supplementation, Omega-3 Fatty Acid… JAMA (2020). https://jamanetwork.com/journals/jama/fullarticle/2772758Khezri S, Sahraian MA, Hosseini H, et al.. Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise… Nutrients (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261319/
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