Albumin/Globulin Ratio is a comparison of the levels of albumin and globulins in the blood. An abnormal ratio may indicate liver disease, kidney disease, or other health problems.
Alanine is a key substrate for albumin synthesis in the liver. Changes in alanine levels may reflect altered albumin production and impact the albumin/globulin ratio.
Zhang, H., Li, Y., & Wang, Y.. Albumin-Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness. Critical Care Medicine (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413056/
Glutamine is an important fuel source for rapidly dividing cells including hepatocytes. Glutamine deficiency may impair albumin synthesis and decrease the albumin/globulin ratio.
Zhang, J., Li, Y., & Wang, Y.. Efficacy of Glutamine-Enriched Nutrition Support for Patients With Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis. Frontiers in Nutrition (2022). https://pubmed.ncbi.nlm.nih.gov/25655622//url
Song, M., & Chan, A. T.. Dietary glutamine, glutamate and mortality: two large prospective cohort studies in the United States. International Journal of Epidemiology (2021). https://academic.oup.com/ije/article/47/1/311/4621367/url
