Explore by Lab Marker
Microalbumin
Microalbumin is a small amount of albumin in the urine that can be an early sign of kidney damage, especially in people with diabetes or high blood pressure.
iollo markers that associate with Microalbumin
Alanine
Like glycine, alanine is an amino acid that can be reabsorbed in the renal tubules. Tubular dysfunction associated with early diabetic kidney disease may cause urinary wasting of alanine in addition to albumin.References
References
Schaub, M. P., et al.. Biomarkers of Acute Kidney Injury. PMC - NCBI (2008). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742480/Matsushita, K., et al.. Low-Grade Albuminuria and Incidence of Cardiovascular Events in Patients With Type 2 Diabetes. Circulation (2006). https://www.ahajournals.org/doi/10.1161/circulationaha.105.538132González, E., et al.. Renal markers for assessment of renal tubular and glomerular dysfunction. PMC (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297548/Kellum, J. A., et al.. A basic science view of acute kidney injury biomarkers. NDT (2014). https://academic.oup.com/ndt/article/29/7/1301/1843636Christensen, R., et al.. Renal albumin absorption in physiology and pathology. Kidney International (2015). https://www.sciencedirect.com/science/article/pii/S0085253815515172
Glycine
Glycine is an amino acid that can be reabsorbed in the proximal tubules of the kidneys. Impaired tubular reabsorption of glycine may lead to increased urinary glycine excretion along with microalbuminuria, an early marker of kidney damage.References
References
J. A. M. Roch-Ramel, A. F. Hofmann, and H. H. Parving. Abnormal glycine betaine content of the blood and urine of diabetic and renal disease patients. Clinical Chemistry (1993). https://pubmed.ncbi.nlm.nih.gov/7850995/Heeyeon Cho and Jae Hyun Kim. Prevalence of microalbuminuria and its associated cardiometabolic risk factors in Korean youth. Hypertension Research (2017). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456094/
Taurine
Taurine is an abundant amino acid in the body. Urinary taurine wasting can occur along with microalbuminuria in the setting of tubular dysfunction and early nephropathy.References
References
Kanbay, M., Gül, H., Korkmaz, A., Yılmaz, U., Yılmaz, G., & Kanbay, A.. Effects of Taurine and Vitamin E on Microalbuminuria, Plasma Metalloproteinase-9, and Serum Type IV Collagen Concentrations in Patients with Type 2 Diabetes Mellitus. Nephrology Dialysis Transplantation (1999). https://karger.com/nef/article/83/4/361/219443/Effects-of-Taurine-and-Vitamin-E-onZhang, Y., Wang, Y., Zhang, J., Zhang, H., Li, Y., & Zhang, X.. Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rats. PLoS One (2014). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953422/Viswanathan, V., Nair, M. B., & Tilak, P.. Effect of taurine and acetylcysteine in attenuating microalbuminuria in type 2 diabetes. Diabetes Research and Clinical Practice (2013). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813118/Chesney, R. W., Han, X., & Patters, A. B.. Taurine and the renal system. Journal of Biomedical Science (2010). https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-S1-S4