Explore by Lab Marker
Antinuclear Antibodies (ANA)
Antinuclear Antibodies (ANA) are antibodies that can be present in autoimmune conditions such as lupus. The presence of ANA can help diagnose these conditions.
iollo markers that associate with Antinuclear Antibodies (ANA)
Arachidonic acid
Arachidonic acid is an omega-6 fatty acid that can be metabolized into pro-inflammatory eicosanoids. Increased levels of arachidonic acid and its inflammatory metabolites may contribute to the production of autoantibodies like ANA in autoimmune conditions.References
References
Not specified. Prostaglandins synthesis. ResearchGate (Not specified). https://www.researchgate.net/figure/Prostaglandins-synthesis-a-Conversion-of-arachidonic-acid-AA-into-prostaglandin-H-2-PGH_fig2_221919679Emily C. Somers, John D. Meeker, and Rita K. Loch-Caruso. Mercury Exposure and Antinuclear Antibodies among Females. NCBI (2015). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529012/Hatem Tallima and Rashika El Ridi. Arachidonic acid: Physiological roles and potential health benefits. NCBI (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052655/
Docosahexaenoic acid
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that helps regulate inflammation. Reduced DHA levels may promote an inflammatory state that facilitates autoantibody production and positive ANA results.References
References
Halade GV, Williams PJ, Veigas JM, Barnes JL, Fernandes G. “Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases”. Frontiers in Immunology (2019). https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02241/fullFernandes G, Fernandes R, Rao B, Veigas JM, Halade GV. “Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune MRL/lpr mice”. Lipids in Health and Disease (2010). https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-44Fernandes G, Fernandes R, Veigas JM, Halade GV. “Omega-3 fatty acid intake suppresses induction of diverse autoantibody specificities in MRL/lpr mice”. Clinical Immunology (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020726/
Eicosapentaenoic acid
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with anti-inflammatory properties. Low levels of EPA may be associated with increased inflammation and autoimmunity, potentially contributing to elevated ANA levels.References
References
Huang, X., Zhang, X., Yang, Y., Zhang, J., Li, X., & Zhou, X.. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Alleviates Lupus Symptoms in Mice. Frontiers in Immunology (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240640/