High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation in the body. High levels of hs-CRP are associated with an increased risk of heart disease and other inflammatory conditions.
Arachidonic acid is a precursor to pro-inflammatory eicosanoids like prostaglandins and leukotrienes. Increased arachidonic acid levels can promote inflammation and elevate hs-CRP.
Huang, CC., Chang, MT., Leu, HB. et al.. Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease. Scientific Reports (2020). https://www.nature.com/articles/s41598-020-65014-z
Glutamic acid is a non-essential amino acid involved in immune function. Elevated glutamate levels have been associated with increased inflammation and higher hs-CRP in some studies.
Lactic acid buildup can occur during inflammation due to increased immune cell activity and glycolysis. Higher lactate levels correlate with inflammatory states and elevated hs-CRP.
Praveen Kumar, Sreeja P, Sreekala S, Sreeja S, Mathew L, Ramkumar S, et al.. High sensitive C-reactive protein as a systemic inflammatory marker and its correlation with lactate dehydrogenase isoenzymes in chronic obstructive pulmonary disease. Journal of Laboratory Physicians (2012). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276029/
Ya L, XH, Yu L, DL, JZ, LY, et al.. Application value of hypersensitive C-reactive protein, lactic acid and myoglobin in the diagnosis of myocarditis. Oncotarget (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507525/
Yuki K, Hiroshi T, Tatsuya K, et al.. Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage, procalcitonin, and lactate in identifying bacterial infection in the emergency department. Scientific Reports (2021). https://www.nature.com/articles/s41598-021-90894-0
Myristic acid is a saturated fatty acid that may promote inflammation when consumed in excess. Some studies link higher myristic acid intake to increased hs-CRP levels.
Fernandez-Real, J.M.; Lopez-Legarrea, P.; Lopez-Miranda, J.; Ricart, W.; Martinez, J.A.. Influence of Diet and Levels of Zonulin, Lipopolysaccharide and C-reactive protein on Cardiometabolic Risk Factors - NCBI. Nutrients (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706658/
Damasceno, N.R.; et al.. Effects of Olive Oil on Markers of Inflammation and Endothelial Dysfunction - MDPI. Nutrients (2015). https://www.mdpi.com/2072-6643/7/9/5356
Palmitic acid is a saturated fatty acid that can activate pro-inflammatory pathways like NF-κB signaling. Elevated palmitic acid is associated with higher hs-CRP in some populations.
Lee, J.E., Kim, J.Y., Kim, M.K., et al.. Longitudinal changes in high sensitivity C-reactive protein and the association with serum uric acid: A systematic review and meta-analysis. Nature Communications (2024). https://www.nature.com/articles/s41598-023-50951-2
Banait, T., Lee, J.H., Kim, J.H., et al.. The association between serum uric acid and high-sensitivity C-reactive protein in Korean adults: A longitudinal study. Cureus (2023). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650935/
