Anion Gap is a measure of the balance between positively and negatively charged electrolytes in the blood. An abnormal anion gap may indicate acid-base imbalances, kidney disease, or other health problems.

iollo markers that associate with Anion Gap Panel


Acetylcarnitine is formed from acetyl-CoA, which if accumulated (e.g. due to PDH deficiency) can be hydrolyzed to acetate anions and increase the anion gap.

Aconitic acid

Aconitic acid is converted to isocitrate in the citric acid cycle. Elevated aconitic acid levels may slightly increase organic anions and the anion gap.

Aspartic Acid

Like glutamic acid, aspartic acid is metabolized to organic anions (e.g. oxaloacetate) that can increase the anion gap if elevated.

Glutamic Acid

Glutamic acid can be converted to alpha-ketoglutarate, an organic anion that contributes to the anion gap when levels are increased.

Hydroxyglutaric acid

Hydroxyglutaric acids are organic acid intermediates. Significant accumulation of these organic anions could increase the anion gap.

Lactic acid

Lactic acid is a key contributor to the anion gap. Elevated lactic acid levels from anaerobic metabolism or impaired clearance can increase the anion gap.

Succinic acid

Succinic acid is an intermediate in the citric acid cycle. Accumulation of succinate anions can modestly contribute to an increased anion gap.