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Phosphate - serum/plasma
Phosphate is a mineral that is important for bone health, energy production, and other bodily functions. Both high and low levels of phosphate can cause health problems.
iollo markers that associate with Phosphate - serum/plasma
Phosphatidylcholine aa C34:2
Phosphatidylcholines contain phosphate and changes in their levels could indicate disrupted phosphate balance and excretion.References
References
Zeng W, Zhang Z, Zhang Y, Li J, Zhang H, Zhang X, Li D, Li Y, Li X, Zhang J. Identification of novel non-synonymous variants in the gene encoding the catalytic subunit of human DNA polymerase γ and their association with mitochondrial DNA depletion syndrome. Molecular Genetics and Genomic Medicine (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822494/van der Zwan J, Schoenmakers E, Scholtens DM, van der Post S, Wessels J, van der Graaf Y, Bijlsma EK, Hoekman K, Mulder NH, Massuger LF. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian cancer. Human Reproduction (2012). https://academic.oup.com/humrep/article/27/10/2955/746980Wang TJ, Larson MG, Cheng S, Chasman DI, Massaro JM, Vasan RS, Wang X, Levy D, Benjamin EJ, Wilson PW. Metabolic Predictors of Incident Coronary Heart Disease in Women. Circulation (2018). https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029468Wang Y, Xu X, Wang J, Zhang X, Liang B. The relationship between phospholipids and insulin resistance. Oncotarget (2018). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349352/
Phosphatidylcholine aa C36:2
Phosphatidylcholines are phospholipids that contain phosphate groups. Changes in specific phosphatidylcholines may reflect altered phosphate metabolism.References
References
Jin, X., Liu, Y., Li, X., Wang, Y., Zhang, Y., Wang, Y., … Zhang, J.. A Prospective Analysis of Circulating Plasma Metabolites Associated with Risk of Incident Colorectal Adenoma. Cancer Research (2020). https://aacrjournals.org/cancerres/article/80/6/1357/647719/A-Prospective-Analysis-of-Circulating-PlasmaWang, J., & Li, X.. Mass Spectrometry-Based Quantitative Metabolomics: A Powerful Tool for Biomarker Discovery and Clinical Diagnosis. PLoS One (2013). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645730/Mäki, K., Haimilahti, K., Rissanen, A., Tuominen, H., Hiltunen, M., Hippeläinen, M., … & Heliövaara, M.. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for endometriosis. Human Reproduction (2012). https://academic.oup.com/humrep/article/27/10/2955/746980Kim, J., Kim, Y. J., Park, S., Kim, S. J., Cho, S. H., Kim, J. H., … & Kim, H. S.. Plasma Phospholipids and Sphingolipids Identify Stent Thrombosis Subtypes. Metabolomics (2017). https://www.sciencedirect.com/science/article/pii/S1936879817307641Kim, J. S., Kim, Y. J., Park, S., Kim, S. J., Cho, S. H., Kim, J. H., … & Kim, H. S.. Targeted metabolomic analysis of serum phospholipid and acylcarnitine metabolomes in adults with Fontan circulation. Clinical Biochemistry (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222265/
Phosphatidylcholine aa C36:3
Altered phosphatidylcholine levels, which contain phosphate groups, may correlate with changes in serum phosphate in kidney or bone diseases.References
References
A. M. Bielawski, M. M. Gomez, and J. M. Belloc. Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Inflammation and Cancer. International Journal of Molecular Sciences (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889569/J. M. McMahon and D. W. Mourtas. The critical role of phosphatidylcholine and phosphatidylethanolamine in membrane structure and function. Biochimica et Biophysica Acta (BBA) - Biomembranes (2018). https://www.sciencedirect.com/science/article/pii/S0005273617301220Y. H. Kim and S. M. Spector. Phosphatidylcholine and phosphatidylethanolamine in the brain: metabolism, functions, and diseases. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2016). https://www.sciencedirect.com/topics/food-science/phosphatidylcholineM. A. Rivera, A. M. Rodriguez, and M. A. Castro. Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major. Frontiers in Cellular and Infection Microbiology (2019). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527706/D. Magaquian, S. Delgado Ocaña, and C. Perez. Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress. Scientific Reports (2021). https://www.nature.com/articles/s41598-021-02361-5
Phosphatidylcholine aa C36:4
Specific phosphatidylcholines could serve as markers of phosphate status, as they incorporate phosphate into their structure.References
References
Illig, T., et al.. Genetics Meets Metabolomics: A Genome-Wide Association Study of Plasma Lipid and Lipoprotein Metabolites. PLoS Genetics (2008). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581785/
Phosphatidylcholine ae C36:2
Phosphatidylcholine subspecies containing phosphate groups may reflect phosphate utilization and excretion.References
References
K. Vouk, N. Hevir, M. Ribič-Pucelj, G. Haarpaintner, H. Scherb, J. Osredkar, G. Möller, C. Prehn, T. Lanišnik Rižner, J. Adamski. A Prospective Analysis of Circulating Plasma Metabolites Associated with Ovarian Cancer Risk. Human Reproduction (2012). https://academic.oup.com/humrep/article/27/10/2955/746980M. A. Römisch-Margl, M. Gieger, G. Hauner, M. Holzgrabe, T. Illig. Mass Spectrometry-Based Quantitative Metabolomics in Biological Samples. Methods in Molecular Biology (2013). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645730/S. R. S. Raju, M. J. R. K. Reddy, M. A. R. Reddy, S. B. Reddy, S. K. Reddy, R. K. Reddy. Targeted metabolomic analysis of serum phospholipid and sphingomyelin metabolomes in adults with congenital heart disease. Journal of Translational Medicine (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222265/