BUN/Creatinine Ratio is a comparison of the levels of BUN and creatinine in the blood that can help differentiate between different types of kidney problems.

iollo markers that associate with BUN/Creatinine Ratio


Arginine is another key amino acid in the urea cycle that is converted to ornithine and urea. Disruption of arginine metabolism could potentially increase BUN and the BUN/Creatinine ratio.


Citrulline is an amino acid that is an important intermediate in the urea cycle. Impairment of the urea cycle can lead to elevated BUN levels and an increased BUN/Creatinine ratio. Citrulline levels may be reduced when the urea cycle is not functioning optimally.


Creatinine is used directly in the calculation of the BUN/Creatinine ratio. Higher creatinine levels will decrease the ratio. Creatinine is a breakdown product of creatine phosphate in muscle, and it is used as an indicator of kidney function.


Ornithine is an amino acid produced in the urea cycle and is important for the detoxification of ammonia. Elevated BUN and BUN/Creatinine ratio may be associated with altered ornithine levels if the urea cycle is impacted.