Urine Hyaline Casts are cylindrical structures that can form in the kidneys and be detected in the urine. The presence of hyaline casts in the urine is a nonspecific finding that may occur in healthy individuals or in certain kidney disorders.
Creatinine is a breakdown product of creatine phosphate in muscle. Elevated blood creatinine levels are an indicator of kidney dysfunction. Hyaline casts can form in the kidney tubules when plasma proteins leak through the glomerular filtration barrier due to kidney damage or disease.
Anna Hernández, MD; Ahaana Singh, Lisa Miklush, PhD, RN, CNS; Jillian Dunbar. Hyaline Casts: What Are They, Causes, Diagnosis, Treatment, and More. Osmosis (2021). https://www.osmosis.org/answers/hyaline-casts
Cystinuria is an inherited disorder that causes high levels of cystine in the urine, which can lead to cystine stones in the kidneys, ureters, and bladder. These stones and crystals can damage kidney tubules and lead to hyaline cast formation.
Elisa Shikata, Ryosuke Hattori, Mitsuo Hara, Tomohiro Nakayama. The Detection of Hyaline Casts in Patients Without Renal Dysfunction. Nihon University School of Medicine (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751402/
Anthony J. Bleyer, Stanislav Kmoch. Tamm Horsfall Glycoprotein and Uromodulin: It Is All about the Tubules!. Clinical Journal of the American Society of Nephrology (2015). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702239/
Elevated homocysteine is a risk factor for cardiovascular and kidney disease. High homocysteine can damage blood vessels and lead to kidney dysfunction, potentially resulting in hyaline cast formation due to glomerular damage allowing proteins into the tubules.
D. Gurda, L. Handschuh, W. Kotkowiak, H. Jakubowski. Homocysteine: Its Possible Emerging Role in At-Risk Population Groups. Amino Acids (2015). https://www.mdpi.com/1422-0067/21/4/1421
Y. M. Smulders, M. Buysschaert, P. E. Wallemacq, M. P. Hermans. Elevated homocysteine levels in type 2 diabetes induce constitutive… Journal of Diabetes Research (2016). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095649/
Anna Hernández, MD, Ahaana Singh, Lisa Miklush, PhD, RN, CNS, Jillian Dunbar. Hyaline Casts: What Are They, Causes, Diagnosis, Treatment, and More. Osmosis (2021). https://www.osmosis.org/answers/hyaline-casts
