Thyroid Peroxidase (TPO) is an enzyme involved in the production of thyroid hormones. The presence of TPO antibodies can indicate an autoimmune thyroid condition such as Hashimoto’s thyroiditis.
Phenylalanine is converted to tyrosine, which is then used for thyroid hormone synthesis catalyzed by TPO. Abnormalities in phenylalanine metabolism could theoretically influence downstream tyrosine availability and TPO-mediated thyroid hormone production.
Tyrosine is a precursor for thyroid hormone synthesis. Thyroid peroxidase (TPO) is an enzyme that catalyzes iodination of tyrosine residues in thyroglobulin for the production of thyroid hormones T3 and T4. Alterations in tyrosine levels could potentially impact TPO activity and thyroid function.
de Vijlder, J.J.M., Bikker, H.. Biochemistry and Physiology of Thyroid Peroxidase. The Peroxidase Multigene Family of Enzymes (2000). https://doi.org/10.1007/978-3-642-58314-8_17
Carvalho, D.P., Ferreira, A.C.F., Coelho, S.M., Moraes, J.M., Camacho, M.A.S., Rosenthal, D.. Thyroid peroxidase activity is inhibited by amino acids. Brazilian Journal of Medical and Biological Research (2000). https://www.scielo.br/j/bjmbr/a/9LgtNdmWGF3VY8K9xfMmPdH/?format=pdf
