Sex Hormone Binding Globulin (SHBG) is a protein that binds to testosterone and estradiol in the blood, regulating their availability for use by the body. High or low levels of SHBG can affect the availability of these hormones and cause symptoms such as decreased libido or infertility.

iollo markers that associate with Sex Hormone Binding Globulin (SHBG)


Alanine is a gluconeogenic amino acid that can promote insulin resistance. Insulin resistance is associated with lower SHBG levels.


Cortisol, a glucocorticoid stress hormone, suppresses SHBG production in the liver. Chronically elevated cortisol is linked to lower SHBG levels.

Dehydroepiandrosterone sulfate

DHEA-S is a precursor to androgens and estrogens. Higher DHEA-S levels are associated with lower SHBG, as SHBG binds to and regulates sex hormone levels.


Glycine is involved in glutathione synthesis and has anti-inflammatory effects. Low glycine may promote inflammation and oxidative stress, leading to reduced SHBG.