Rheumatoid Arthritis Factor (RF) is an antibody that can be present in autoimmune conditions such as rheumatoid arthritis. The presence of RF can help diagnose these conditions.
Arachidonic acid is a precursor to inflammatory mediators like prostaglandins and leukotrienes. Increased arachidonic acid levels may contribute to the inflammatory processes involved in rheumatoid arthritis and elevated RF.
Tański, Wojciech, Natalia Świątoniowska-Lonc, Mateusz Tabin, and Beata Jankowska-Polańska. The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis. Nutrients (2022). https://doi.org/10.3390/nu14051030
Tateishi, N., Kaneda, Y., Kakutani, S., et al.. Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E 2 content in rat adjuvant-induced arthritis model. Lipids in Health and Disease (2015). https://doi.org/10.1186/1476-511X-14-3
Glutamic acid is an excitatory neurotransmitter that can have pro-inflammatory effects. Dysregulation of glutamate signaling has been implicated in the pathogenesis of rheumatoid arthritis.
L. R. Egsmose, M. B. Christensen, J. J. Holm, L. S. H. Jacobsen, and K. H. Jensen. “Endogenous glutamate in association with inflammatory and hormonal factors in patients with rheumatoid arthritis”. Arthritis Research & Therapy (2009). https://arthritis-research.biomedcentral.com/articles/10.1186/ar2763
Marzieh Soleimani Damaneh, Nastaran Aryaeian, Seyedeh Khajoenia, et al.. “The association between dietary intake of branched-chain amino acids and odds and severity of rheumatoid arthritis”. Scientific Reports (2024). https://doi.org/10.1038/s41598-024-56610-4
