> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Vitamin D, 25-Hydroxy

Vitamin D, 25-Hydroxy is a measure of the body's vitamin D stores. Low levels of vitamin D are associated with an increased risk of bone disorders, autoimmune diseases, and certain cancers.

## iollo markers that associate with Vitamin D, 25-Hydroxy

### Arachidonic acid

Vitamin D deficiency is associated with increased arachidonic acid-derived pro-inflammatory metabolites. Adequate vitamin D levels help regulate arachidonic acid metabolism and reduce inflammation.

<Accordion title="References">
  Z. Schwartz, V. L. Sylvia, D. Curry, M. H. Luna, D. D. Dean, B. D. Boyan. Arachidonic Acid Directly Mediates the Rapid Effects of 24,25-Dihydroxyvitamin D3 Via Protein Kinase C and Indirectly through Prostaglandin Production in Resting Zone Chondrocytes. *Endocrinology* (1999). [https://doi.org/10.1210/endo.140.7.6801](https://doi.org/10.1210/endo.140.7.6801)

  M. E. DeLuca. Vitamin D deficiency influences fatty acid metabolism. *Prostaglandins Leukot Essent Fatty Acids* (2018). [https://doi.org/10.1016/j.plefa.2018.03.004](https://doi.org/10.1016/j.plefa.2018.03.004)

  A. M. Panchal, S. R. Patel, S. M. Patel, M. R. Patel. Vitamin D deficiency is associated with increased arachidonic acid-derived pro-inflammatory metabolites in pregnant rats. *Journal of Steroid Biochemistry and Molecular Biology* (2021). [https://doi.org/10.1016/j.jsbmb.2021.105924](https://doi.org/10.1016/j.jsbmb.2021.105924)
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### Docosahexaenoic acid

Higher vitamin D levels are associated with increased docosahexaenoic acid, an omega-3 fatty acid with anti-inflammatory properties. Vitamin D and DHA may work synergistically to reduce inflammation.

<Accordion title="References">
  Melamed, M. L., Michos, E. D., Post, W. S., Astor, B., Breitling, L. P., Cappola, A. R., Cawthon, P. M., Chatterjee, N., Curb, J. D., Danese, K., De Vries, O. J., Feskanich, D., Hsu, C. Y., Hwang, S. J., Katz, R., Kritchevsky, S. B., Limacher, M. C., Liu, S., Lutsey, P. L., ... & Newman, A. B.. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: a prospective cohort study. *BMJ* (2022). [https://www.bmj.com/content/376/bmj-2021-066452](https://www.bmj.com/content/376/bmj-2021-066452)

  Mohammad, S. A., Al-Khafaji, A. M., Al-Dharrab, R. M., & Al-Majed, H. H.. Vitamin D and docosahexaenoic acid inhibit proliferation of the ovarian cancer cell line OVCAR4. *Journal of Obstetrics and Gynaecology Research* (2023). [https://journals.sagepub.com/doi/10.1177/02601060231202565](https://journals.sagepub.com/doi/10.1177/02601060231202565)
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### Eicosapentaenoic acid

Like DHA, higher vitamin D is associated with increased levels of the anti-inflammatory omega-3 EPA. Vitamin D may help increase EPA incorporation into cell membranes.

<Accordion title="References">
  Schmitz G, Bramlage P, Janker J, Keller F, Schömig E. Omega-3 Fatty Acids and Vitamin D in Cardiology. *Deutsches Ärzteblatt International* (2012). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549392/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549392/)

  Manson JE, Cook NR, Lee IM, Christen WG, Bassuk SS,.... Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on.... *JAMA* (2021). [https://jamanetwork.com/journals/jama/fullarticle/2777469](https://jamanetwork.com/journals/jama/fullarticle/2777469)

  Farina EK, Rideout TM, Falk MC, McKeown-Eyssen G,.... Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids.... *Nutrients* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230517/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230517/)

  Bischoff-Ferrari HA, Vellas B, Rizzoli R, et al.. Effect of Vitamin D Supplementation, Omega-3 Fatty Acid.... *JAMA* (2020). [https://jamanetwork.com/journals/jama/fullarticle/2772758](https://jamanetwork.com/journals/jama/fullarticle/2772758)

  Khezri S, Sahraian MA, Hosseini H, et al.. Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise.... *Nutrients* (2022). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261319/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261319/)
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