> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Nitrite

Urine Nitrite is a measure of the amount of nitrite in the urine. The presence of nitrite in the urine may indicate a urinary tract infection.

## iollo markers that associate with Nitrite

### Arginine

Arginine is the precursor for nitric oxide synthesis. Nitric oxide can be oxidized to form nitrite. Higher arginine availability may increase nitric oxide production and nitrite levels.

<Accordion title="References">
  Thiago Silveira Alvares, Carlos Adam Conte-Junior, Joab Trajano Silva, Vânia Margaret Flosi Paschoalin. Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects. *Nutrition & Metabolism* (2012). [https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-54](https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-54)

  AK Kiani, G Bonetti, MC Medori, P Caruso, P Manganotti, F Fioretti, S Nodari, ST Connelly, M Bertelli. Dietary supplements for improving nitric-oxide synthesis. *Journal Preventive Medicine and Hygiene* (2022). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710401/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710401/)
</Accordion>

### Asymmetric dimethylarginine

ADMA is an endogenous inhibitor of nitric oxide synthase. Higher ADMA levels can suppress nitric oxide production from arginine, potentially leading to reduced nitrite levels.

<Accordion title="References">
  Authors not specified in the provided snippet. Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity, and plasma testosterone levels. *Journal of Inorganic Biochemistry* (2017). [https://www.sciencedirect.com/science/article/pii/S1109966617303949](https://www.sciencedirect.com/science/article/pii/S1109966617303949)

  Larsen FS, et al.. Associations of Plasma Nitrite, l-Arginine and Asymmetric Dimethylarginine with Disease Severity and Outcome in Patients with Necrotizing Soft Tissue Infection. *SHOCK* (2018). [https://journals.lww.com/shockjournal/fulltext/2018/06000/associations\_of\_plasma\_nitrite,\_l\_arginine\_and.8.aspx](https://journals.lww.com/shockjournal/fulltext/2018/06000/associations_of_plasma_nitrite,_l_arginine_and.8.aspx)
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### Ornithine

Ornithine and citrulline can be interconverted in the urea cycle. Changes in ornithine levels may impact citrulline and downstream nitric oxide and nitrite production.

<Accordion title="References">
  Not specified. "Enzymes of Arginine Metabolism". *ScienceDirect* (2023). [https://www.sciencedirect.com/science/article/pii/S0022316623031206](https://www.sciencedirect.com/science/article/pii/S0022316623031206)

  Not specified. "Urinary metabolites characteristic of urea-cycle amino acid deficiency". *The Journal of Clinical Investigation* (1975). [https://www.sciencedirect.com/science/article/abs/pii/0026049575901444](https://www.sciencedirect.com/science/article/abs/pii/0026049575901444)

  Aleš Horák, Andrew E. Allen. "Common origin of ornithine–urea cycle in opisthokonts and stramenopiles". *Nature Communications* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542463/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542463/)
</Accordion>