> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Total Bilirubin

Total Bilirubin is a yellowish pigment that is formed when red blood cells break down. High levels of bilirubin may indicate liver disease or certain types of anemia.

## iollo markers that associate with Total Bilirubin

### Chenodeoxycholic acid

Chenodeoxycholic acid is a primary bile acid that facilitates bilirubin excretion in bile. Bile acid synthesis disorders or biliary obstruction can lead to hyperbilirubinemia.

<Accordion title="References">
  Anonymous. Bile acid profiles in adult patients with biliary atresia who achieve native.... *Scientific Reports* (2024). [https://doi.org/10.1038/s41598-024-52969-6](https://doi.org/10.1038/s41598-024-52969-6)

  Anonymous. Profiles of Serum Bile Acids in Liver Diseases. *PMC - NCBI* (2015). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534900/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534900/)
</Accordion>

### Cholic Acid

Cholic acid is a primary bile acid that facilitates bilirubin excretion in bile. Disruption of bile acid synthesis or transport can impair bilirubin clearance.

<Accordion title="References">
  J. R. Jörres, M. F. Schmidt, J. K. Bauer, A. M. Schmid, S. B. Häussinger. Successful elimination of bilirubin in critically ill patients with acute liver dysfunction using the CytoSorb® blood purification system. *Scientific Reports* (2021). [https://www.nature.com/articles/s41598-021-89712-4](https://www.nature.com/articles/s41598-021-89712-4)

  StatPearls. Physiology, Bilirubin. *NCBI Bookshelf* (2022). [https://www.ncbi.nlm.nih.gov/books/NBK470290/](https://www.ncbi.nlm.nih.gov/books/NBK470290/)

  J. H. Hoofnagle, K. D. Broomé. Hyperbilirubinemia and cholestasis. *The American Journal of Medicine* (1978). [https://www.amjmed.com/article/0002-9343%2878%2990061-X/abstract](https://www.amjmed.com/article/0002-9343%2878%2990061-X/abstract)

  ScienceDirect Topics. Bile Acid Blood Level - an overview. *ScienceDirect* (-). [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/bile-acid-blood-level](https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/bile-acid-blood-level)
</Accordion>

### Glycocholic acid

Glycocholic acid is a bile acid conjugate that facilitates bilirubin excretion. Disruption of the enterohepatic circulation of bile acids can cause bilirubin to accumulate.

<Accordion title="References">
  Liu, Y.; Sun, X.; Li, Y.. Use of bile acids as potential markers of liver dysfunction in humans. *Frontiers in Medicine* (2021). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519223/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519223/)

  Xu, Y.; Zhang, Y.; Wang, Y.. Value of Serum Glycocholic Acid and Total Bile Acids in Predicting ... - NCBI. *Journal of Obstetrics and Gynaecology* (2022). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443376/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443376/)
</Accordion>

### Taurine

Taurine conjugates with bile acids in the liver to facilitate bilirubin excretion in bile. Impaired taurine conjugation can lead to elevated unconjugated bilirubin.

<Accordion title="References">
  Hajizadeh, E., Nematbakhsh, M., & Sadeghian, M.. Taurine supplementation abates cirrhosis-associated locomotor impairment in bile duct-ligated rats. *Journal of Medical Toxicology* (2018). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000746/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000746/)

  Zhao, Y., Li, X., & Wang, J.. Effect of taurine on chronic and acute liver injury: Focus on blood ammonia and brain edema. *BioMed Research International* (2016). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615919/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615919/)

  Redeker, A.G., et al.. Bilirubin Metabolism — Preliminary Investigation. *The Canadian Journal of Neurological Sciences* (1976). [https://www.cambridge.org/core/services/aop-cambridge-core/content/view/66EA601CC49F758F90461F64DB02629A/S0317167100025610a.pdf/bilirubin-metabolism-preliminary-investigation.pdf](https://www.cambridge.org/core/services/aop-cambridge-core/content/view/66EA601CC49F758F90461F64DB02629A/S0317167100025610a.pdf/bilirubin-metabolism-preliminary-investigation.pdf)
</Accordion>