> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Prolactin

Prolactin is a hormone produced by the pituitary gland that stimulates milk production in women. High levels of prolactin can cause symptoms such as irregular periods, infertility, and erectile dysfunction in men.

## iollo markers that associate with Prolactin

### Dopamine

Dopamine is the primary inhibitor of prolactin secretion from the anterior pituitary gland. Decreased dopamine levels or dopamine receptor antagonism leads to increased prolactin secretion.

<Accordion title="References">
  Polly Kirsch, Jessica Kunadia, Shruti Shah, Nidhi Agrawal. Metabolic effects of prolactin and the role of dopamine agonists: A review. *Endocrine Connections* (2022). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562454/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562454/)

  E.M. Wolfe, M.A. Stadel, S.S. Fleshner. Prolactin and dopamine: What is the connection? A Review Article. *Frontiers in Neuroendocrinology* (2008). [https://journals.sagepub.com/doi/10.1177/0269216307087148](https://journals.sagepub.com/doi/10.1177/0269216307087148)

  Nira Ben-Jonathan, Robert Hnasko. Dopamine as a Prolactin (PRL) Inhibitor. *Endocrine Reviews* (2001). [https://academic.oup.com/edrv/article/22/6/724/2424026](https://academic.oup.com/edrv/article/22/6/724/2424026)
</Accordion>

### Tyrosine

Tyrosine is the amino acid precursor for dopamine synthesis. Changes in tyrosine availability could influence dopamine levels and consequently impact prolactin secretion.

<Accordion title="References">
  Mohamed Saleem, Helen Martin, Penelope Coates. Prolactin Biology and Laboratory Measurement: An Update on Physiology and Current Analytical Issues. *NCBI* (2018). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069739/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069739/)

  Katalin Kovács, et al.. Serum prolactin as a biomarker for the study of intracerebral dopamine effect in adult patients with phenylketonuria. *NCBI* (2016). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864969/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864969/)

  J. W. H. Lee, et al.. Tyrosine administration decreases serum prolactin levels in chronically reserpinized rats by enhancing the synthesis and release of dopamine. *Science Direct* (1979). [https://www.sciencedirect.com/science/article/pii/0024320579903941](https://www.sciencedirect.com/science/article/pii/0024320579903941)

  J. M. Lerant, et al.. Prolactin-Regulated Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Mediobasal Hypothalamus. *Endocrinology* (1980). [https://academic.oup.com/endo/article/146/1/93/2499963](https://academic.oup.com/endo/article/146/1/93/2499963)

  J. W. H. Lee, et al.. Tyrosine administration decreases serum prolactin levels in chronically reserpinized rats by enhancing the synthesis and release of dopamine. *Science Direct* (1979). [https://www.sciencedirect.com/science/article/abs/pii/0024320579903941](https://www.sciencedirect.com/science/article/abs/pii/0024320579903941)
</Accordion>