> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Herpes Simplex Virus 1 & 2 (IgG)*

Herpes Simplex Virus 1 & 2 (IgG) are the two main types of herpes virus that cause oral and genital herpes. Blood tests can detect IgG antibodies to the viruses, indicating current or past infection.

## iollo markers that associate with Herpes Simplex Virus 1 & 2 (IgG)\*

### Arginine

Arginine is required for herpes simplex virus replication. Higher arginine levels may support increased viral activity and antibody response.

<Accordion title="References">
  Jane Y. Chang, Curt Balch, Joseph Puccio, Hyung S. Oh. A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus. *Herpes simplex virus-1 (HSV-1) and -2 (HSV-2) ... article* (2023). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301284/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301284/)
</Accordion>

### Lysine

Lysine supplementation is thought to reduce herpes simplex virus replication and outbreaks by competing with arginine. Lower lysine levels may increase risk.

<Accordion title="References">
  Mailoo, V.J.; Rampes, S.. Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. *Integrative Medicine* (2017). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419779/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419779/)

  Pedrazini, M.C.; da Silva, M.H.; Groppo, F.C.. L-Lysine: Its Antagonism with L-Arginine in Controlling Viral Infection. *British Journal of Clinical Pharmacology* (2022). [https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.15312](https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.15312)

  Chang, J.Y.; Balch, C.; Puccio, J.; Oh, H.S.. A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus. *Viruses* (2023). [https://www.mdpi.com/1999-4915/15/6/1314](https://www.mdpi.com/1999-4915/15/6/1314)
</Accordion>