> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.
# High-sensitivity C-reactive protein (hs-CRP)
High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation in the body. High levels of hs-CRP are associated with an increased risk of heart disease and other inflammatory conditions.
## iollo markers that associate with High-sensitivity C-reactive protein (hs-CRP)
### Arachidonic acid
Arachidonic acid is a precursor to pro-inflammatory eicosanoids like prostaglandins and leukotrienes. Increased arachidonic acid levels can promote inflammation and elevate hs-CRP.
Huang, CC., Chang, MT., Leu, HB. et al.. Therapeutic and Prognostic Significance of Arachidonic Acid in Acute Decompensated Heart Failure. *Circulation Research* (2022). [https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320548](https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320548)
Sone, T., et al.. Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study. *Atherosclerosis* (2013). [https://www.sciencedirect.com/science/article/abs/pii/S0021915013005698](https://www.sciencedirect.com/science/article/abs/pii/S0021915013005698)
Imamura, F., et al.. Impact of the dietary fatty acid intake on C-reactive protein levels in US adults: NHANES 2005-2010. *PLoS One* (2017). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319491/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319491/)
Huang, CC., Chang, MT., Leu, HB. et al.. Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease. *Scientific Reports* (2020). [https://www.nature.com/articles/s41598-020-65014-z](https://www.nature.com/articles/s41598-020-65014-z)
### Glutamic Acid
Glutamic acid is a non-essential amino acid involved in immune function. Elevated glutamate levels have been associated with increased inflammation and higher hs-CRP in some studies.
Xu, J., Li, X., Li, Y., Zhang, J., Li, J., & Li, X.. High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function. *Brain Sciences* (2023). [https://www.mdpi.com/article/10.3390/brainsci13040658/s1](https://www.mdpi.com/article/10.3390/brainsci13040658/s1)
Tang, Y., Liang, P., Chen, J., Zhang, Y., & Zhang, J.. The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population. *Immunity & Ageing* (2018). [https://immunityageing.biomedcentral.com/articles/10.1186/s12979-018-0126-7](https://immunityageing.biomedcentral.com/articles/10.1186/s12979-018-0126-7)
### Lactic acid
Lactic acid buildup can occur during inflammation due to increased immune cell activity and glycolysis. Higher lactate levels correlate with inflammatory states and elevated hs-CRP.
Praveen Kumar, Sreeja P, Sreekala S, Sreeja S, Mathew L, Ramkumar S, et al.. High sensitive C-reactive protein as a systemic inflammatory marker and its correlation with lactate dehydrogenase isoenzymes in chronic obstructive pulmonary disease. *Journal of Laboratory Physicians* (2012). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276029/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276029/)
Ya L, XH, Yu L, DL, JZ, LY, et al.. Application value of hypersensitive C-reactive protein, lactic acid and myoglobin in the diagnosis of myocarditis. *Oncotarget* (2019). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507525/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507525/)
Yuki K, Hiroshi T, Tatsuya K, et al.. Comparison of sPLA2IIA performance with high-sensitive CRP neutrophil percentage, procalcitonin, and lactate in identifying bacterial infection in the emergency department. *Scientific Reports* (2021). [https://www.nature.com/articles/s41598-021-90894-0](https://www.nature.com/articles/s41598-021-90894-0)
### Myristic acid
Myristic acid is a saturated fatty acid that may promote inflammation when consumed in excess. Some studies link higher myristic acid intake to increased hs-CRP levels.
Fernandez-Real, J.M.; Lopez-Legarrea, P.; Lopez-Miranda, J.; Ricart, W.; Martinez, J.A.. Influence of Diet and Levels of Zonulin, Lipopolysaccharide and C-reactive protein on Cardiometabolic Risk Factors - NCBI. *Nutrients* (2021). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706658/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706658/)
Damasceno, N.R.; et al.. Effects of Olive Oil on Markers of Inflammation and Endothelial Dysfunction - MDPI. *Nutrients* (2015). [https://www.mdpi.com/2072-6643/7/9/5356](https://www.mdpi.com/2072-6643/7/9/5356)
Chen, L.; et al.. Impact of the dietary fatty acid intake on C-reactive protein levels in US adults - NCBI. *Nutrition Research* (2017). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319491/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319491/)
Soleimani, Z.; et al.. The Role of Flaxseed in Improving Human Health - MDPI. *Nutrients* (2020). [https://www.mdpi.com/2227-9032/11/3/395](https://www.mdpi.com/2227-9032/11/3/395)
### Palmitic acid
Palmitic acid is a saturated fatty acid that can activate pro-inflammatory pathways like NF-κB signaling. Elevated palmitic acid is associated with higher hs-CRP in some populations.
Lee, J.E., Kim, J.Y., Kim, M.K., et al.. Longitudinal changes in high sensitivity C-reactive protein and the association with serum uric acid: A systematic review and meta-analysis. *Nature Communications* (2024). [https://www.nature.com/articles/s41598-023-50951-2](https://www.nature.com/articles/s41598-023-50951-2)
Banait, T., Lee, J.H., Kim, J.H., et al.. The association between serum uric acid and high-sensitivity C-reactive protein in Korean adults: A longitudinal study. *Cureus* (2023). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650935/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650935/)