> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Ferritin

Ferritin is a protein that stores iron in the body. Low levels of ferritin can indicate iron deficiency, while high levels may indicate iron overload or inflammation.

## iollo markers that associate with Ferritin

### Alanine

Alanine is a substrate for the synthesis of glucose, which requires iron-containing enzymes. Altered ferritin levels could affect glucose production from alanine and alanine levels.

<Accordion title="References">
  A. López-García, M. A. Gómez-Ambrosi, F. Casanova, et al.. Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase in Nonalcoholic Fatty Liver Disease: A Prospective Study. *Nutrients* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695258/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695258/)

  X. Liu, Y. Li, J. Li, et al.. Serum iron and risk of nonalcoholic fatty liver disease and its histological severity: A prospective cohort study. *Scientific Reports* (2021). [https://www.nature.com/articles/s41598-021-89991-x](https://www.nature.com/articles/s41598-021-89991-x)

  S. K. Al-Habdan, A. A. Al-Mazyad, A. A. Al-Johani, et al.. Clinical and Biochemical Assessment of Liver Function Test and Its Correlation with Serum Ferritin in Thalassemia Major Patients. *Cureus* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205361/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205361/)
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### Carnitine

Carnitine is involved in fatty acid metabolism and energy production in mitochondria. Ferritin levels may impact carnitine utilization since iron is a cofactor for carnitine synthesis enzymes. Abnormal ferritin could thus alter carnitine levels.

<Accordion title="References">
  B. R. Bieber, J. L. Lamar, and J. M. Saavedra. Inadequate iron availability as a possible cause of low serum carnitine. *Journal of Inherited Metabolic Disease* (1989). [https://link.springer.com/article/10.1007/BF02093725](https://link.springer.com/article/10.1007/BF02093725)

  S. S. Ahmed, S. A. Al-Dharrab, and A. Al-Megrin. Serum carnitine levels in children with iron-deficiency anemia. *Nutrition* (2006). [https://pubmed.ncbi.nlm.nih.gov/16728358/](https://pubmed.ncbi.nlm.nih.gov/16728358/)
</Accordion>

### Glutamic Acid

Glutamic acid is involved in the citric acid cycle and amino acid metabolism. Iron-containing enzymes like aconitase are critical for the citric acid cycle. Ferritin levels may thus influence glutamic acid utilization.

<Accordion title="References">
  Zhang, W., Nassiri, F., Mason, W., Aldape, K.D., Zadeh, G., & Chen, E.X.. "Glutamine reliance in cell metabolism". *Experimental & Molecular Medicine* (2020). [https://www.nature.com/articles/s12276-020-00504-8](https://www.nature.com/articles/s12276-020-00504-8)

  ScienceDirect Topics. "Krebs Cycle - an overview". *ScienceDirect* (nan). [https://www.sciencedirect.com/topics/earth-and-planetary-sciences/krebs-cycle](https://www.sciencedirect.com/topics/earth-and-planetary-sciences/krebs-cycle)

  StatPearls. "Biochemistry, Citric Acid Cycle". *NCBI Bookshelf* (nan). [https://www.ncbi.nlm.nih.gov/books/NBK541072/](https://www.ncbi.nlm.nih.gov/books/NBK541072/)
</Accordion>