> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Eosinophils

Eosinophils are a type of white blood cell involved in allergic reactions and parasitic infections. High levels of eosinophils can indicate these conditions.

## iollo markers that associate with Eosinophils

### Arachidonic acid

Arachidonic acid is converted to inflammatory leukotrienes that activate and attract eosinophils. Elevated arachidonic acid may indicate increased eosinophil-mediated inflammation.

<Accordion title="References">
  Drazen, J. M., Schaub, B., & Austen, K. F.. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and Associated Data. *Proceedings of the National Academy of Sciences* (2008). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206596/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206596/)

  Blanchard, C., & Gleich, G. J.. Biology of the Eosinophil. *Cold Spring Harbor Perspectives in Biology* (2010). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109275/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109275/)

  Majumdar, S. K., & Chatterjee, A.. Emerging Roles of Eosinophils and Eosinophil-Derived Lipid Mediators in Health and Disease. *Frontiers in Immunology* (2012). [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00270/full](https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00270/full)
</Accordion>

### Histamine

Histamine released by mast cells and basophils can activate eosinophils and increase their levels. Elevated histamine may suggest an allergic response involving eosinophils.

<Accordion title="References">
  Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, et al.. "In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4 Receptor". *Frontiers in Immunology* (2018). [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02119/full](https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02119/full)

  nan. "Eosinophil - an overview". *ScienceDirect Topics* (nan). [https://www.sciencedirect.com/topics/medicine-and-dentistry/eosinophil](https://www.sciencedirect.com/topics/medicine-and-dentistry/eosinophil)
</Accordion>