> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Basophils

Basophils are a type of white blood cell involved in allergic reactions and asthma. High levels of basophils can indicate these conditions.

## iollo markers that associate with Basophils

### Histamine

Histamine is released by basophils and mast cells during allergic reactions and inflammation. Elevated histamine levels are directly associated with increased basophil counts and activity.

<Accordion title="References">
  Maintz, L., & Novak, N.. Histamine Intolerance: The Current State of the Art - PMC - NCBI. *NCBI* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463562/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463562/)

  Youman, J. D., Taddeini, L., & Cooper, T.. Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia. *Arch Intern Med* (1973). [https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/580962](https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/580962)

  Kovacova-Hanuskova, E., Gavliakova, S., & Fitzner, J.. Histamine and histamine intolerance. *ScienceDirect* (2015). [https://www.sciencedirect.com/science/article/pii/S0002916523280533](https://www.sciencedirect.com/science/article/pii/S0002916523280533)

  Bazan, A., & Bazan, D.. Histamine, histamine intoxication and intolerance. *Elsevier* (2015). [https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-histamine-histamine-intoxication-intolerance-S0301054615000932](https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-histamine-histamine-intoxication-intolerance-S0301054615000932)

  Huang, Y., Chen, J., & Zhang, L.. Association of basophil parameters with disease severity and duration in patients with coronavirus disease 2019 (COVID-19). *PMC* (2021). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012729/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012729/)
</Accordion>

### Tryptophan

Tryptophan and its metabolites like serotonin may influence basophil recruitment and activation, as serotonin can be released by activated basophils. However, the relationship is not as direct as with histamine.

<Accordion title="References">
  Mendel Friedman. Tryptophan: A Unique Role in the Critically Ill - PMC - NCBI. *PMC - NCBI* (2021). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583765/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583765/)

  Mendel Friedman. Tryptophan metabolism promotes immune evasion in human .... *The Lancet* (2023). [https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964%2823%2900305-5/fulltext](https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964%2823%2900305-5/fulltext)

  Mendel Friedman. Analysis, Nutrition, and Health Benefits of Tryptophan - PMC - NCBI. *PMC - NCBI* (2018). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158605/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158605/)

  Mendel Friedman. Citrulline and kynurenine to tryptophan ratio: potential EED .... *ScienceDirect Topics* (2023). [https://www.sciencedirect.com/topics/neuroscience/tryptophan](https://www.sciencedirect.com/topics/neuroscience/tryptophan)

  Mendel Friedman. Tryptophan and its metabolites: implications for human health and disease. *Nature* (2023). [https://www.nature.com/articles/s41598-023-28114-0](https://www.nature.com/articles/s41598-023-28114-0)
</Accordion>