> ## Documentation Index
> Fetch the complete documentation index at: https://markers.iollo.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Adiponectin

Adiponectin is a hormone produced by fat cells that helps regulate glucose and lipid metabolism. Low levels of adiponectin are associated with obesity, insulin resistance, and type 2 diabetes.

## iollo markers that associate with Adiponectin

### Alanine

Increased alanine levels are associated with insulin resistance and may decrease adiponectin secretion from adipose tissue.

<Accordion title="References">
  Mantzoros, C. S., Flier, J. S., & Spiegelman, B. M.. Adiponectin in insulin resistance: lessons from translational research. *Endocrine Reviews* (2009). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793112/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793112/)

  Kim, S. H., Kim, S. Y., Kim, J. Y., & Park, J. Y.. Adiponectin, ALT and family history as critical markers for the ... - NCBI. *Diabetes Research and Clinical Practice* (2020). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831204/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831204/)

  Achari, A. E., & Jain, S. K.. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. *International Journal of Molecular Sciences* (2017). [https://www.mdpi.com/1422-0067/18/6/1321](https://www.mdpi.com/1422-0067/18/6/1321)

  Emanuelli, B., & Liu, X.. Mechanisms by which adiponectin reverses high fat diet-induced .... *Proceedings of the National Academy of Sciences* (2020). [https://www.pnas.org/doi/10.1073/pnas.1922169117](https://www.pnas.org/doi/10.1073/pnas.1922169117)
</Accordion>

### Glutamine

Glutamine supplementation has been shown to increase adiponectin levels, possibly by reducing inflammation and oxidative stress.

<Accordion title="References">
  Samocha-Bonet, D., et al.. Glutamine Links Obesity to Inflammation in Human White Adipose Tissue. *Diabetes* (2011). [https://diabetes.diabetesjournals.org/content/60/10/2632](https://diabetes.diabetesjournals.org/content/60/10/2632)

  Abboud, K.Y., et al.. Oral glutamine supplementation reduces obesity, pro-inflammatory markers, and improves insulin sensitivity in DIO wistar rats and reduces waist circumference in overweight and obese humans. *Nutrients* (2019). [https://www.mdpi.com/2072-6643/11/5/1153](https://www.mdpi.com/2072-6643/11/5/1153)

  nan. Correlation between plasma glutamate and adiponectin in obese mice. *Unpublished manuscript* (2024). [\[url\]](\[url])
</Accordion>